کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1266537 1496876 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ultrasound mediated destruction of multifunctional microbubbles for image guided delivery of oxygen and drugs
ترجمه فارسی عنوان
تخریب میکروب های چند منظوره از طریق سونوگرافی برای تحویل اکسیژن و مواد مخدر هدایت تصویر
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
چکیده انگلیسی

We synthesized multifunctional activatible microbubbles (MAMs) for ultrasound mediated delivery of oxygen and drugs with both ultrasound and fluorescence imaging guidance. Oxygen enriched perfluorocarbon (PFC) compound was encapsulated in liposome microbubbles (MBs) by a modified emulsification process. DiI dye was loaded as a model drug. The ultrasound targeted microbubble destruction (UTMD) process was guided by both ultrasonography and fluorescence imaging modalities. The process was validated in both a dialysis membrane tube model and a porcine carotid artery model. Our experiment results show that the UTMD process effectively facilitates the controlled delivery of oxygen and drug at the disease site and that the MAM agent enables ultrasound and fluorescence imaging guidance of the UTMD process. The proposed MAM agent can be potentially used for UTMD-mediated combination therapy in hypoxic ovarian cancer.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ultrasonics Sonochemistry - Volume 28, January 2016, Pages 31–38
نویسندگان
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