کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1266778 | 972300 | 2013 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Facile sonochemical synthesis of novel pyrazolyne derivates at ambient conditions Facile sonochemical synthesis of novel pyrazolyne derivates at ambient conditions](/preview/png/1266778.png)
Claisen–Schmidt condensation reaction of 4-acetamidoacetophenone with aromatic aldehydes under ultrasonic irradiation affords acetylaminochalcones (yields: 71–90%) which also under ultrasonic irradiation and in the presence of sodium acetate and acetic acid aqueous undergo facile and clean cyclocondensation with hydrazine to afford 3-(4-acetamidophenyl)-5-(aryl)-1-H-pyrazolines. The pyrazolines were obtained in good to excellent yields (81–89%), and were characterized by conventional spectral data. The work-up is simple and the results obtained indicate that, unlike classical heating, ultrasonic irradiation results in higher yields, shorter reaction times (1.5–2.3 h) and milder conditions.
► We reported a simple synthesis to obtain pyrazolinic derivatives.
► The advantages of carrying out the reaction induced by U.S radiation.
► Comparable methods reported in the literature regarding reaction time and yield.
► Efficient protocol for the U.S assisted synthesis of heterocyclic compounds.
Journal: Ultrasonics Sonochemistry - Volume 20, Issue 4, July 2013, Pages 1033–1036