Pro-oxidant activity of nickel (II) pyridoxal complexes. Synthesis, characterization and peroxidase activity assays

• Nickel(II) Schiff base complexes derived from condensation of pyridoxal and aryl-thiol were versatile as pro-oxidant activity.
• The complexes show variation in carbon spacers between pyridoxal molecules: ethane, propane and butane.
• Mononuclear nickel (II) complexes showed good pro-oxidant in the reaction of the phenol-aminoantipyrine adduct.

ABSTRACTThe synthesis of Ni (II) complexes with pro-oxidant applications has demonstrated many advantages, such as accelerated reactions, solution stability and with high selectivity reactions. In this work we describe the synthesis, characterization and structural analysis of nickel ([(Ni)(C30H28N4O4S2)]);([(Ni)(C31H30N4O4S2)]) and ([(Ni)(C33H37N4O4S2)]·DMF — complex 3) complexes with ligands obtained from the condensation of pyridoxal and aryl-thiol amines and their application as a pro-oxidant in the reaction of the phenol-aminoantipyrine adduct. The complexes show variation in carbon spacers between pyridoxal molecules: ethane, propane and butane. It was found that the spacer two carbons containing the most significant as the pro-oxidant activity.

Ni(II)-pyridoxal complexes with preliminar peroxidase activity.Figure optionsDownload as PowerPoint slide