Tetrakis(1-3-diazinane-2-thione)platinum(II) chloride monohydrate complex: Synthesis, spectroscopic characterization, crystal structure and in vitro cytotoxic activity against A549, MCF7, HCT15 and HeLa human cancer lines

• [Pt(Diaz)4]Cl2 complex was the most effective on MCF7 cell line compare to cisplatin.
• The crystal structure new platinum (II) complex [Pt(Diaz)4]Cl2 has been reported.
• The complex was characterized by CHNS, IR and 13C, 15N and 195Pt NMR measurements.

This communication reports on the synthesis, crystal structure and anticancer activities of a new Pt(II) complex [Pt(Diaz)4]Cl2 · H2O of a heterocyclic thione, where Diaz = 1,3-diazinane-2-thione. Solid state 195Pt, 15N and 13C NMR are also reported along with other spectroscopic data. The cytotoxic evaluation of the complex against A549, MCF7, HCT15 and HeLa human cancer lines is reported. The title compound was found to be a better cytotoxic agent against MCF7 than cisplatin.

This communication reports on the synthesis, crystal structure and anticancer activities of a new Pt(II) complex [Pt(Diaz)4]Cl2 · H2O of heterocyclic thione, where Diaz = 1,3-diazinane-2-thione. Solid state 195Pt, 15N and 13C NMR are also reported along with other spectroscopic techniques. The cytotoxic evaluation against A549, MCF7, HCT15 and HeLa human cancer lines is reported.Figure optionsDownload as PowerPoint slide