کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1301757 | 1498943 | 2014 | 4 صفحه PDF | دانلود رایگان |
• A series of bis-(benz)imidazolium salts and Ag–NHC are prepared.
• All compounds are characterized by physico-chemical methods.
• Ag complexes exhibit linear coordination geometry.
• Complexes displayed promising antibacterial activity compared with salts.
A series of p-xylyl/2,6-lutidinyl linked bis-(benz)imidazolium salts 1–4 and their binuclear Ag–NHC complexes 5–8 have been reported. Salts 1–4 were synthesized by the successive N-alkylation method, first reacting 1H-(benz)imidazole with α,α′-dichloro-p-xylene/2,6-dibromomethyl pyridine followed by the reaction of an appropriate alkyl bromide. Binuclear Ag complexes 5–8 having bis-NHC periphery with linear coordination modes have been prepared by the reaction of salts 1–4 with Ag2O at a mild reaction condition. Compounds 1–8 have been fully characterized by spectral and analytical techniques. Additionally, molecular structure of salt 4 and complex 6 has been unambiguously elucidated by single crystal XRD studies. The structure of complex 6 is a metallomacrocycle having two Ag centers supported by two bis-NHC ligands. Preliminary in vitro antibacterial studies against Escherichia coli and Staphylococcus aureus revealed the superior activity of Ag complexes compared to azolium salts with 12.4 ± 1.5 to 27.5 ± 2 mm diameter of the zone of bacterial growth inhibition.
Four N,N′-disubstituted bis-(benz)imidazolium salts and their Ag–NHC complexes are reported. All compounds were tested for antibacterial activity showing that all four complexes are promising antibacterial agents.Figure optionsDownload as PowerPoint slide
Journal: Inorganic Chemistry Communications - Volume 47, September 2014, Pages 56–59