An amino acid coordinated vanadium (IV) complex: Synthesis, structure, DFT calculations and VHPO mimicking catalytic bromoperoxidation of organic substrates

• Oxovanadium(IV) complex of l-valine [VO(sal-l-val)(phen)]
• Structural and spectral parameters are supported by DFT calculations.
• Haloperoxidase activity
• Peroxidative bromination of olefinic alcohols
• Establishment of the mechanism of catalytic activity.

A new VHPO mimicking oxovanadium(IV) complex [VO(sal-l-val)(phen)] (sal-l-val = Schiff base derived from salicylaldehyde and l-valine; phen = 1,10-phenanthroline) has been synthesized and characterized by elemental analysis, UV–vis, IR spectroscopy, ESI-MS, EPR and single crystal XRD studies. The structural and spectral parameters were further supported using DFT calculations. The complex was found to exhibit vanadium dependent haloperoxidase (VPHO) activity.

A new oxidovanadium complex [VIVO(sal-l-val)(phen)] has been designed and synthesized with the aim of developing active biocatalyst. The compound mimics the VHPO activity by effecting in vitro bromination of olefinic alcohols to the corresponding brominated products with good efficiency. The mechanism of catalytic activity has been established and confirmed by ESI-MS mass spectrometry.Figure optionsDownload as PowerPoint slide