Effects of salicylate derivate on the competing reaction of chromium(III) complex [Cr(III)(R-SA)(en)2]Cl with apoovotransferrin

The substitutive group R on SA (H2SA = salicylic acid) has positive influence on the charge density of phenolate O and carboxylate O atom, which directly affect the stability of the R-SA-Cr(III)-OTf intermediate formed in the reaction of chromium complexes [Cr(III)(R-SA)(en)2]Cl with apoovotransferrin (OTf).