کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1302546 | 974698 | 2011 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Interaction of organotin(IV) moieties with nucleic acid constituent: Synthesis, structural characterization and anti-inflammatory activity of tri-i-propyltin(IV) and diorganotin(IV) derivatives of guanosine Interaction of organotin(IV) moieties with nucleic acid constituent: Synthesis, structural characterization and anti-inflammatory activity of tri-i-propyltin(IV) and diorganotin(IV) derivatives of guanosine](/preview/png/1302546.png)
Tri-i-propyltin(IV) and diorganotin(IV) derivatives of guanosine of the general formulae, i-Pr3Sn(HGuO).H2O and [R2Sn(O)(HGuO).H2O]n, where R = Me, n-Oct and Ph; H2GuO = Guanosine, have been synthesized by either sodium salt or azeotropic removal of water method. The bonding and coordination behavior in these derivatives are discussed on the basis of FT-IR, multinuclear 1H, 13C and 119Sn NMR and 119Sn Mössbauer spectroscopic studies. These investigations suggest that guanosine acts as monoanionic monodentate coordinating through O-2′ of the ribofuranose group. Diorganotin(IV) derivatives of guanosine have a polymeric structure with SnOSn bridges and cis-disposition of the organic groups in a distorted trigonal-bipyramidal geometry around the tin atom. 119Sn Mössbauer and 119Sn NMR spectral data of tri-i-propyltin(IV) derivative support a penta-coordinate distorted trigonal-bipyramidal structure having equatorial organic groups, and involving a water molecule and O-2′ of the ribofuranose group in the axial positions. Some extent of intermolecular hydrogen-bonding involving water or (OH) groups leading to some degree of polymerization could not be ignored. Tri-i-propyltin(IV) and diorganotin(IV) derivatives of guanosine exhibited very low anti-inflammatory activity (~ 7.51–9.21% inhibition) at 40 mg kg− 1 dose and LD50 values > 200 mg kg− 1 in albino rats.
Tri-i-propyltin(IV) and diorganotin(IV) derivatives of guanosine have been synthesized and characterized. Diorganotin(IV) derivatives have a polymeric structure with SnOSn bridges, while tri-i-propyltin(IV) derivative has a distorted trigonal-bipyramidal structure with equatorial organic groups, and a water molecule and O-2′ of the ribofuranose group in the axial positionsFigure optionsDownload as PowerPoint slideResearch highlights
► Interaction of tri-i-propyltin(IV) and diorganotin(IV) moieties with guanosine.
► Diorganotin (IV) derivatives have a polymeric structure with Sn-O-Sn bridges.
► Tri-i-propyltin(IV) derivative has a distorted trigonal-bipyramidal structure with equatorial organic groups.
► All of these derivatives exhibit very low anti-inflammatory activity in albino rats.
Journal: Inorganic Chemistry Communications - Volume 14, Issue 9, September 2011, Pages 1381–1385