کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1302736 | 974708 | 2011 | 5 صفحه PDF | دانلود رایگان |

A series of mono- and dinuclear (η6-arene) ruthenium(II) complexes were prepared by reaction of thiosemicarbazone ligands derived from benzaldehyde and ruthenium(II) precursors of the general formula [Ru(η6-arene)(μ-Cl)Cl]2, where arene = p-iPrC6H4Me or C6H5C3H6COOH. These complexes were characterized by NMR and IR spectroscopy, ESI-mass spectrometry and elemental analysis. The molecular structure of the mononuclear p-cymene complex was determined by X-ray diffraction analysis, revealing a pseudo-tetrahedral piano stool conformation and a bidentate N,S coordination mode of the thiosemicarbazone ligand. The complexes and ligands were evaluated for their in vitro cytotoxicity against the WHCO1 oesophageal cancer cell line.
Mono- and dinuclear (η6-arene) ruthenium(II) complexes were prepared by the reaction of thiosemicarbazone ligands derived from benzaldehyde and ruthenium(II) precursors of the general formula [Ru(η6-arene)(μ-Cl)Cl]2. Selected complexes displayed moderate activity against the WHCO1 oesophageal cancer cell line.Figure optionsDownload as PowerPoint slideResearch Highlights
► Monomeric and dimeric thiosemicarbazone ligands were prepared.
► Mono- and binuclear ruthenium(II) arene thiosemicarbazone complexes were synthesized.
► Complexes show a pseudo-tetrahedral geometry and bidentate N,S ligand coordination.
► Selected compounds showed moderate in vitro cytotoxicity.
Journal: Inorganic Chemistry Communications - Volume 14, Issue 6, June 2011, Pages 956–960