Synthesis and characterization of platinum(II) oligopyridine-peptide conjugates

• Formation of Pt-N bond via solid phase synthesis.
• A general synthetic method for Pt(II) oligopyridine peptide conjugates.
• Structural characterization of complex [Pt(trpy)(pyridine-4-carboxylic acid)](NO3).

Complexes of the general formulae [Pt(trpy)(cpy)]NO3, where cpy = pyridine-2-carboxylic acid, pyridine-3-carboxylic and pyridine-4-carboxylic acid (1)–(3), have been synthesized and characterized. The molecular structure of (3) has been determined by X-ray single crystal diffraction. The resin-immobilized ligand Lys-Lys-4-CO-py (L) interacts with the [Pt(trpy)H2O](NO3)2 via solid phase synthesis, forming the complex [Pt(trpy)(4-CO-py-Lys1-Lys2CONH2)](NO3)4, which has been characterized by 1H NMR and mass spectrometry.

Mixed ligand Pt(II) complexes with 2,2′:6′,2″ terpyridine and pyridine carboxylic acids have been synthesized and characterized. The resin-immobilized ligand Lys2-Lys1-4-CO-py interacts with [Pt(trpy)(H2O)](NO3)2, forming via solid phase synthesis the complex [Pt(trpy)(4-CO-py-Lys1-Lys2CONH2)](NO3)4.Figure optionsDownload as PowerPoint slide