A novel Ru(II) complex derived from hydroxydiamine as a potential antitumor agent: Synthesis and Structural Characterization

A novel Ru(II)-Schiff base complex has been synthesized by the interaction of ligand, 1,3-bis{[(E)-(2-chlorophenyl)methylidene]amino}-2-propanol, L with [RuCl2(PPh3)3]. The structure of ligand, L has been determined on the basis of X-ray diffraction while the geometry of the Ru(II) complex has been ascertained by FT-IR, 1H, 13 C{1H}, 31P{1H} NMR and UV–vis studies. The in vitro antitumor activity of these compounds was assessed by examining their ability to inhibit cell proliferation against human breast and pancreatic cancer cell lines. The results show a dose-dependent anti-proliferative effect and induction of apoptotic cell death in both the cancer cell lines, thus indicating pharmacological significance of Ru(II) complex against cancer.

A novel Schiff base ligand and its Ru(II) complex has been synthesized and characterized by various spectroscopic techniques followed by their screening to examine their ability to inhibit cell proliferation in a number of human cancer cell lines (MDA-MB-231) and (BxPC-3).Figure optionsDownload as PowerPoint slideHighlights
► Synthesis of a novel Schiff base ligand and its Ru(II)-complex.
► Characterized by various physico-chemical and spectroscopic studies.
► In vitro antitumor screening proved them potent growth inhibitor.