Improved deposition and deprotection of silane tethered 3,4 hydroxypyridinone (HOPO) ligands on functionalized nanoporous silica

An improved synthesis of a 3,4 hydroxypyridinone (HOPO) functionalized mesoporous silica is described. Higher 3,4-HOPO monolayer ligand loadings have been achieved, resulting in better performance. Performance improvements were demonstrated with the capture of U(VI) from human blood, plasma and filtered river water.

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► Improvements made in the deprotection chemistry of 3,4-HOPO ligands bound to a silica surface.
► First demonstration of deposition of unprotected 3,4 HOPO directly onto silica surface.
► Notable improvement for collection of U from human blood, plasma and river water.