Palladium (II) and platinum (II) complexes containing organometallic thiosemicarbazone ligands: Synthesis, characterization, X-ray structures and antitubercular evaluation

• Pd(II) and Pt(II) complexes containing ferrocenyl and cyrhetrenyl thiosemicarbazone
• The organometallic TSCs are coordinated under the anionic thiolate form.
• All complexes showed moderate activity against M. tuberculosis.

A new series of palladium (II) and platinum (II) complexes containing ferrocenyl and cyrhetrenyl thiosemicarbazone ligands were synthesized and characterized. The two-step reaction of the organometallic thiosemicarbazones with i) K2MCl4 and ii) PPh3 and their subsequent recrystallization from CH2Cl2/hexane yielded the binuclear complexes [Mˋ{MLn(η5-C5H4)C(H)NNC(S)NHR}–(Cl)(PPh3)] (M′Pd, Pt; MLnRe(CO)3, FeCp; RH, CH3). The structures of the products were inferred from elemental analyses and IR, 1H and 31P NMR spectroscopies. The molecular structures of 2b and 3d were confirmed by single crystal X-ray analysis. All complexes were screened in vitro against Mycobacterium tuberculosis and exhibited only moderate activity in the low micromolar range.

Pd(II) and Pt(II) complexes containing ferrocenyl and cyrhetrenyl thiosemicarbazone ligands were synthesized and characterized by spectroscopy and X-ray crystallography. The chelation of organometallic-TSCs through the thiolate form was inferred by 1H-NMR and confirmed by X-ray crystallography studies. The activity of the new Pd(II) and Pt(II) complexes was evaluated in vitro against Mycobacterium tuberculosis. All complexes showed only moderate antitubercular activity.Figure optionsDownload as PowerPoint slide