کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1306653 | 975097 | 2008 | 5 صفحه PDF | دانلود رایگان |
The present study has compared the effects of a total of 17 ligands on Zr(IV)-assisted hydrolysis of the dipeptide Gly–Gly (60 °C, pH 6.8–7.4, t = 4 h and t = 10 h). The macrocyclic azacrown ether ligands 1,4,10,13-tetraoxa-7,16-diazacyclooctadecane and 1,4,10-trioxa-7,13-diazacyclopentadecane produced the overall highest amounts of hydrolysis, followed by the open-chain ligand 2-(2-aminoethoxy)-ethanol. While it was not necessary to have a ring structure to enhance Zr(IV) reactivity, the structural feature “ROCH2CH2OCH2CH2NR” appeared to contribute to increased levels of peptide cleavage.
Seventeen ligands were compared to observe their effects on Zr(IV)-assisted hydrolysis of Gly–Gly (60 °C, pH 6.8–7.4, t = 4 and 10 h). The diazacrown ethers 1,4,10,13-tetraoxa-7,16-diazacyclooctadecane and 1,4,10-trioxa-7,13-diazacyclopentadecane and the open-chain ligand 2-(2-aminoethoxy)-ethanol produced the most cleavage, indicating that the structural feature “ROCH2CH2OCH2CH2NR” contributes to peptide hydrolysis.Figure optionsDownload as PowerPoint slide
Journal: Inorganic Chemistry Communications - Volume 11, Issue 5, May 2008, Pages 521–525