کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1313479 | 1499315 | 2016 | 7 صفحه PDF | دانلود رایگان |
• 1,1-Difluoroethylation and 2,2,2-trifluoroethylation of ArMgBr proceeded smoothly.
• Co/diamine-catalyst showed the satisfactory activity in this reaction.
• The choice of diamine ligand and solvent are very important for excellent yields.
Cobalt/diamine-catalyzed 1,1-difluoroethylation and 2,2,2-trifluoroethylation of aryl Grignard reagents with 1,1-difluoroethyl and 2,2,2-trifluoroethyl halides were investigated. With regard to the 1,1-difluoroethylation, 1,2-bis(dimethylamino)-2-methylpropane, which has been rarely used in the cross-coupling reactions, gave the highest yield among the diamine ligands tested. In the 2,2,2-trifluoroethylation, trans-1,2-bis(dimethylamino)cyclohexane provided the desired products in satisfactory yields with not only 2,2,2-trifluoroethyl iodide but also chloride. This Co/diamine catalyst was also effective for the coupling with other partially fluorinated alkyl halides in the presence of appropriate diamine ligands.
The combined use of Co/diamine catalyzed 1,1-difluoroethylation and 2,2,2-trifluoroethylation of aryl Grignard reagents with 1,1-difluoroethyl and 2,2,2-trifluoroethyl halides, providing the desired products in satisfactory yields.Figure optionsDownload as PowerPoint slide
Journal: Journal of Fluorine Chemistry - Volume 185, May 2016, Pages 96–102