Copper-mediated trifluoromethylation of diaryliodonium salts with difluoromethyltriflate

• Trifluoromethylation of diaryliodonium salts was described.
• The trifluoromethylation was carried out at room temperature for 5 min.
• The reaction could be used for the radiosynthesis of [18F]trifluoromethylarenes.

The reaction of diaryliodonium salts with difluoromethyltriflate in the presence of TBAT and CuTC gave the corresponding trifluoromethylated arenes in moderate yields. Compared to other difluorocarbene-derived trifluoromethylation reactions, the current one proceeded at mild reaction conditions (room temperature) within short reaction time (5 min).

Trifluoromethylation of diaryliodonium salts with difluoromethyltriflate in the presence of TBAT and CuTC was carried out at room temperature for 5 min.Figure optionsDownload as PowerPoint slide