BrØsted acid-catalyzed electrophilic trifluoromethylthiolation of indoles using thermally stable trifluoromethylthiolating reagent

• Trifluoromethylthiolation of indoles were achieved efficiently.
• Catalytic amount of BrØsted acid was used to activate the trifluoromethylthiolating reagent.
• Reactions were compatible with a variety of functional groups.

A BrØsted acid-catalyzed electrophilic trifluoromethylthiolation of indoles under mild conditions is described. The reaction was insensitive to moisture and oxygen, that should allow for easy handling. In addition, the reaction is compatible with a variety of functional groups.

Figure optionsDownload as PowerPoint slide