Reactions of organozinc reagents with potassium bromodifluoroacetate

• Synthesis of gem-difluorinated compounds.
• Preparation and reactions of fluorinated organozinc reagents.
• Reactions of potassium boromodifluoroacetate.

A practical method for the synthesis of gem-difluorinated compounds from organozinc reagents is described. Potassium bromodifluoroacetate serves as a source of CF2-fragment, which is inserted into carbonzinc bond of organozinc reagents. The intermediate difluorinated organozinc species can be protonated, brominated or coupled with allylic electrophiles.

Assembling of gem-difluorinated compounds from organozinc reagents, potassium bromodifluoroacetate and electrophiles is described.Figure optionsDownload as PowerPoint slide