کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1313617 | 1499329 | 2015 | 5 صفحه PDF | دانلود رایگان |
• We achieved the synthesis of (E)-β-(trifluoromethyl)styrenes.
• All reagents used here were easily available and inexpensive.
• The products showed high to excellent stereoselectivity.
A practical and convenient synthesis of (E)-β-(trifluoromethyl)styrenes has been achieved by the reaction of commercially available halothane (HCFC-123B1) and hydrazones prepared in advance in situ, in the presence of 1,2-ethylenediamine and a catalytic amount of CuCl2·2H2O at room temperature. The products showed acceptable to high yields and high to excellent stereoselectivity. This handy synthetic method provided easy access to a variety of (E)-β-(trifluoromethyl)styrenes.
A practical and convenient synthesis of (E)-β-(trifluoromethyl)styrenes has been achieved by the reaction of halothane (HCFC-123B1) and hydrazones in the presence of 1,2-ethylenediamine and a catalytic amount of CuCl2·2H2O at room temperature.Figure optionsDownload as PowerPoint slide
Journal: Journal of Fluorine Chemistry - Volume 171, March 2015, Pages 169–173