Trifluoroethoxy group as a leaving group for regioselective sequential substitution reactions of 5-trifluoromethylpyrimidine derivative with heteroatom nucleophiles

- Regioselective substitution of 2,4-bis(2,2,2-trifluoroethoxy)-5-(trifluoromethyl)pyrimidine.
- Preparation of 2-substituted 5-(trifluoromethyl)pyrimidine derivatives with aniline derivatives.
- Preparation of 2-substituted 5-(trifluoromethyl)pyrimidine derivatives with lithium alkoxides.
- Preparation of 2- and 4-substituted 5-(trifluoromethyl)pyrimidine derivatives.