Study on the synthesis of toluene-2,4-diisocyanate via amine and carbonyl fluoride

• Six main factors of the experimental conditions for the synthesis of TDI via amine and COF2 were studied and optimized.
• The total yield of TDI based on TDA was raised to be 92.3%.
• The influence of the excess COF2 left in the reaction system was studied in detail by a one-pot method.
• The gap between the laboratory and the industrial application will be decreased quickly.

We presented recently a synthesis of toluene-2,4-diisocyanate (TDI) as one of the nine examples to verify the feasibility of an industrial appealing two-step method for isocyanates synthesis via amines and carbonyl fluoride (COF2). Because more investigation was considered to be necessary for future industrial application, the two-step synthesis processes of TDI were studied in detail herein. The total yield of TDI increased 5.6% under the optimized experimental conditions. The influence of the excess COF2 left in the reaction system was studied carefully according to a one-pot method.

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