Synthesis of 3-trifluoromethyl-2-(diethoxyphosphoryl)imidazo[1,2-a]pyridines

• The convenient synthesis of (pyridin-2-yl)perfluoropropionamides was proposed.
• The synthesis N-(pyridin-2-yl)perfluoropropanimidoyl chloride was developed.
• The first of 3-CF3-2-(phosphoryl)imidazo[1,2-a]pyridines was synthesized.

The first representatives of 3-trifluoromethyl-2-(dialkoxyphosphoryl)imidazo[1,2-a]pyridines have been synthesized by the reaction of N-(pyridin-2-yl)-perfluoropropanimidoyl chlorides with triethyl phosphite.

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