کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1313793 | 1499332 | 2014 | 8 صفحه PDF | دانلود رایگان |
• Sixteen novel fluoro-substituted coumarin hydrazones were prepared and characterized.
• One-pot method was found to be more convenient than the reported method.
• The use of microwave reduced the reaction time.
• Solvent-free conditions make the reaction greener.
• Recovered TsOH/SiO2 is recyclable.
Sixteen novel fluoro-substituted coumarin hydrazones were synthesized from a series of ethyl 2-hydroxy-2-(trifluoromethyl)-2H-chromene-3-carboxylates with supported acid catalyst under microwave-assisted one-pot and solvent free conditions. The structures of synthesized compounds were confirmed by IR, 1H NMR, 13C NMR, HRMS and single crystal X-ray diffraction. Compared with the reported reaction conditions, the new method has the advantages of shorter reaction time, simple work-up procedure and environmental friendliness. The supported catalyst can be recovered easily and reused with little change in its activity.
Sixteen novel fluoro-substituted coumarin hydrazones were prepared with one-pot method under microwave-assistant and solvent-free conditions.Figure optionsDownload as PowerPoint slide
Journal: Journal of Fluorine Chemistry - Volume 168, December 2014, Pages 1–8