Fluorous bis(oxazolines) ligand: Synthesis and application in Kabachnik-Fields reaction

• A novel fluorous bis(oxazolines) has been synthesized.
• A mild and efficient method has been developed in Kabachnik-Fields reaction.
• The method was applicable for a wide range of substrates.
• The fluorous ligand could be easily recovered and reused.

A novel fluorous bis(oxazolines) ligand was synthesized with 70% overall yield in 5 steps starting from 5-aminoisophthalic acid. The ligand was applied in the one-pot synthesis of α-aminophosphonates via copper-catalyzed Kabachnik-Fields reaction, giving the corresponding products in moderate to excellent yields under mild conditions. Furthermore, the fluorous ligand could be easily recovered and reused for four times without significant loss of activity.

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