Synthesis of polyfluoroaryl-containing 1,2,3-triazoles by reaction of polyfluoroarenes, sodium azide and active methylene ketones/esters

• A one-pot three-component method for the synthesis of polyfluoroaryl-containing 1,4,5-trisubstituted 1,2,3-triazoles was reported.
• The reactions proceeded under mild condition without any catalyst.
• The addition of Na2CO3 is essential for efficient conversion.

A series of polyfluoroaryl-containing 1,4,5-trisubstituted 1,2,3-triazoles were synthesized via a one-pot three-component reaction of polyfluoroarenes, sodium azide and active methylene ketones/esters by using CH3CN/H2O as solvent in the presence of Na2CO3 at room temperature.

A series of polyfluoroaryl-containing 1,4,5-trisubstituted 1,2,3-triazoles were synthesized via a one-pot three-component reaction of polyfluoroarenes, sodium azide and active methylene ketones/esters by using CH3CN/H2O as solvent in the presence of Na2CO3 at room temperature.Figure optionsDownload as PowerPoint slide