Efficient synthesis of 2-trifluoromethyl quinolines via base-assisted propargyl-allenyl isomerization and aza-electrocyclization of trifluoromethylated alkynyl imines

• Base-assisted electrocyclization of trifluoromethylated alkynyl imines.
• The reaction via propargyl-allenyl isomerization and aza-electrocyclization.
• The reaction afforded 2-trifluoromethylated quinolines in high yields.

A mild and efficient base-mediated propargyl-allenyl isomerization and aza-electrocyclization reaction of trifluoromethylated alkynyl imines have been developed. This method provides a convenient access to 2-trifluoromethylated quinolines in high efficiency.

A mild and efficient base-mediated propargyl-allenyl isomerization and aza-electrocyclization reaction of trifluoromethylated alkynyl imines have been developed. This method provides a convenient access to 2-trifluoromethylated quinolines in high efficiency.Figure optionsDownload as PowerPoint slide