Copper-mediated trifluoromethylation of 5-iodotriazole with (trifluoromethyl)trimethylsilane promoted by silver carbonate

• A new method for the copper-mediated trifluoromethylation of 5-iodotriazole was reported.
• The (trifluoromethyl)trimethylsilane was used as trifluoromethylating reagent.
• The addition of silver carbonate is essential for efficient conversion.

A novel and mild method for copper-mediated trifluoromethylation of 5-iodotriazole using (trifluoromethyl)trimethylsilane (Me3SiCF3) as trifluoromethylating reagent with the assistance of Ag2CO3 was developed.

A novel and mild method for the copper-mediated trifluoromethylation of 5-iodotriazole using (trifluoromethyl)trimethylsilane as trifluoromethylating reagent with the assistance of Ag2CO3 was developed.Figure optionsDownload as PowerPoint slide