Synthesis and applications of fluorinated nucleoside analogues

The synthesis of fluorinated highly modified nucleoside analogues—carbanucleosides, aromatic nucleosides, acyclic nucleosides and related derivatives are reviewed.

The synthesis of fluorinated highly modified nucleoside analogues are reviewed.Figure optionsDownload as PowerPoint slideHighlights
► Highly modified fluorinated analogues of nucleosides are overviewed.
► Synthesis and design of fluorinated carbocyclic nucleosides.
► Aromatic nucleoside isosteres as probes of noncovalent bonding in DNA.
► Fluorinated acyclic nucleosides as antiviral agents and tracers for PET.