N-2-Iodobenzylcinchoninium bromide is effective for catalytic enantioselective trifluoromethylation of azomethine imines in Solkane® 365mfc

Solkane® 365mfc (1,1,1,3,3-pentafluorobutane, CF3CH2CF2CH3) is proven to be an environmental benign alternative solvent for the catalytic enantioselective trifluoromethylation of azomethine imines 1. High chemical yields and enantioselectivities (up to 96% ee) were achieved by employing previously unknown and structurally simple cinchona alkaloid ammonium salt, N-2-iodobenzylcinchoninium bromide 3d as a catalyst.

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► Solkane® 365mfc is an environmental benign solvent for the trifluoromethylation.
► Solkane® 365mfc is a solvent for the enantioselective trifluoromethylation.
► Iodobenzylcinchoninium bromide affects an asymmetric trifluoromethylation.
► Solkane® 365mfc is 1,1,1,3,3-pentafluorobutane, CF3CH2CF2CH3.