Reaction of gem-difluorinated organozinc reagents with β-nitrostyrenes

• Reactions of fluorinated organozinc reagents.
• Reactions of β-nitrostyrenes.
• Copper-catalyzed nitro group substitution.

A novel reactivity pattern of gem-difluorinated organozincs in copper(I) catalyzed reaction with β-nitrostyrenes is described. The reaction proceeds not as conjugate addition, but as nitro group substitution furnishing alkenes as single E-isomers in moderate yields.

Nitro group substitution in copper-catalyzed reaction of gem-difluorinated organozinc reagents with β-nitrostyrenes is described.Figure optionsDownload as PowerPoint slide