کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1313963 | 1499326 | 2015 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
[3 + 2] Cycloaddition of arynes with CF3CHN2: Access to 3-trifluoromethyl-1H-indazoles
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی معدنی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
• [3 + 2] Cycloaddition reactions of arynes and CF3CHN2 were developed.
• A series of 3-trifluoromethyl-1H-indazoles were synthesized under mild reaction conditions.
• CsF in conjunction with TEBAC([Et3NBn]+Cl−) were used.
Efficient [3 + 2] cycloaddition reactions of arynes and CF3CHN2 were developed in the presence of fluoride in conjunction with TEBAC. Structurally distinct 3-trifluoromethyl-1H-indazoles were obtained in good to high yields with moderate regioselectivities. This experimentally simple process facilitates the access to potential biologically active 3-trifluoromethyl-indazoles from readily available starting materials.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Fluorine Chemistry - Volume 174, June 2015, Pages 88–94
Journal: Journal of Fluorine Chemistry - Volume 174, June 2015, Pages 88–94
نویسندگان
Long Sun, Jing Nie, Yan Zheng, Jun-An Ma,