کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1313985 | 1499335 | 2014 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: One-pot two-step sequential transformation: Highly efficient construction of o-2,3,5,6-tetrafluorobenzonitrile substituted oximes ethers One-pot two-step sequential transformation: Highly efficient construction of o-2,3,5,6-tetrafluorobenzonitrile substituted oximes ethers](/preview/png/1313985.png)
• A facile access to a variety of o-2,3,5,6-tetrafluorobenzonitrile substituted oximes ethers.
• One-pot two-step sequential procedure.
• Process involving in situ formation of aryl oximes followed by tandem SNAr of pentafluorobenzonitrile via highly selective C4F bond cleavage.
• The reaction carried out in aqueous medium.
A practical variety of o-2,3,5,6-tetrafluorobenzonitrile substituted oximes ethers bearing broad functional groups were synthesized in moderate to good yields. The key highlight of this disclosure involving a one-pot two-step tandem procedure in aqueous media: the in situ formation of aryl aldehydes or ketones oximes followed by the SNAr reaction with pentafluorobenzonitrile via the high selective CF bond cleavage.
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Journal: Journal of Fluorine Chemistry - Volume 165, September 2014, Pages 101–108