کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1314047 | 1499359 | 2012 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Synthesis of N-substituted α,α-difluoro-β-aminophosphonates by addition of diethyl lithiodifluoromethylphosphonate to imines Synthesis of N-substituted α,α-difluoro-β-aminophosphonates by addition of diethyl lithiodifluoromethylphosphonate to imines](/preview/png/1314047.png)
Addition of diethyl lithiodifluoromethylphosphonate to N-substituted imines provides N-substituted α,α-difluoro-β-aminophosphonates. N-Alkyl, aryl, or Boc substituted aldimines give good to high yields in these reactions, while in ketimine series, only activated N-(2,2,2-trifluoro-1-phenylethylidene)aniline showed high reactivity.
Addition of diethyl lithiodifluoromethylphosphonate to N-substituted aldimines or activated ketimines provides N-substituted α,α-difluoro-β-aminophosphonates.Figure optionsDownload as PowerPoint slideHighlights
► Diethyl lithiodifluoromethylphosphonate adds to N-substituted imines to provide N-substituted α,α-difluoro-β-aminophosphonates.
► Reactions with N-aryl or N-alkyl aldimines provide high yields of products.
► In ketimine series only activated N-(2,2,2-trifluoro-1-phenylethylidene)aniline showed high reactivity.
Journal: Journal of Fluorine Chemistry - Volume 141, September 2012, Pages 76–82