Novel fluorinated dialkylphosphonatocholines: Synthesis, physicochemical properties and antiprotozoal activities against Acanthamoeba spp.

• Synthesis of fluorinated gemini zwitterionic surfactants.
• The physicochemical properties expressed as micellar and solubilization properties.
• Biological activities of prepared compounds tested against Acanthamoeba spp.

The synthesis of four new organophosphorous gemini surfactants is presented. They belong to the class of dialkylphosphonatocholines. Tails are represented with two octyl groups both non or partially fluorinated. The synthesis was performed by reaction of alkylphosphonic acids with choline derivatives in the presence of 2,4,6-triisopropylbenzenesulfonyl chloride. The micellar, surface active, and solubilization properties of new surfactants were studied. Antiprotozoal activities were tested against Acanthamoeba lugdunensis and Acanthamoeba quina.

Synthesis, physicochemical properties and antiprotozoal activities against Acanthamoeba spp. of some new partially fluorinated dialkylphosphonatocholines were described.Figure optionsDownload as PowerPoint slide