کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1314054 1499336 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Approaches for the introduction of fluorinated substituents into [1,2,3]Triazolo[1,5-a]pyridines
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Approaches for the introduction of fluorinated substituents into [1,2,3]Triazolo[1,5-a]pyridines
چکیده انگلیسی


• Novel trifluoromethyl triazolopyridines have been synthesized.
• Trifluoromethylated pyridines have been obtained from triazolopyridines.
• A fluorine mediated triazolopyridine dimerization was found.
• Imidazo[1,5-a]pyridines have been synthesized from triazolopyridines by reaction of this heterocycles with Selectfluor.

[1,2,3]Triazolo[1,5-a]pyridines functionalization with a trifluoromethyl group has been achieved for the first time using different synthetic strategies. Furthermore, these scaffolds have been employed as starting material in the synthesis of new 2,6-disubstituted pyridines containing the trifluoromethyl group, compounds that are not available using other methodologies. A fluorine-mediated triazolopyridine dimerisation is described, improving the previously known synthetic method. Preliminary studies focused on exploring triazolopyridines reactivity with electrophilic fluorine have revealed a new approach for the obtainment of imidazopyridines.

Several approaches aimed at the fluorination of [1,2,3]triazolo[1,5-a]pyridines have been explored. Novel trifluoromethyl substituted pyridines have been synthesized from triazolopyridines. Fluorination attempts have yielded two new synthetic routes for the obtention of triazolopyridines dimers and imidazo[1,5-a]pyridines.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Fluorine Chemistry - Volume 164, August 2014, Pages 44–50
نویسندگان
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