کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1314067 | 1499364 | 2012 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Regioselective synthesis of 5-ethoxycarbonyl-, 5-acetyl- and 5-trifluoroacetyl-6-trifluoromethylsalicylates by one-pot cyclizations of 1,3-bis(trimethylsilyloxy)-1,3-butadienes with 3-alkoxy-2-alken-1-ones Regioselective synthesis of 5-ethoxycarbonyl-, 5-acetyl- and 5-trifluoroacetyl-6-trifluoromethylsalicylates by one-pot cyclizations of 1,3-bis(trimethylsilyloxy)-1,3-butadienes with 3-alkoxy-2-alken-1-ones](/preview/png/1314067.png)
5-Ethoxycarbonyl-, 5-trifluoroacetyl-, and 5-acetyl-6-trifluoromethylsalicylates were prepared by one-pot cyclizations of 1,3-bis(trimethylsilyloxy)-1,3-butadienes with 3-alkoxy-2-alken-1-ones. The reactions proceeded with very good regioselectivity by conjugate addition of the terminal carbon atom of the diene to the enone and subsequent cyclization. The cyclization proceeded in most cases via the trifluoroacetyl group.
5-Ethoxycarbonyl-, 5-acetyl- and 5-trifluoroacetyl-6-trifluoromethylsalicylates were efficiently prepared by one-pot cyclizations of 1,3-bis(trimethylsilyloxy)-1,3-butadienes with 3-alkoxy-2-alken-1-ones.Figure optionsDownload as PowerPoint slideHighlights
► Trifluorinated arenes were prepared by a one-pot procedure.
► The products are not readily available by other methods.
► The reactions proceed with very good regioselectivity.
Journal: Journal of Fluorine Chemistry - Volume 136, April 2012, Pages 38–42