Preparation of enantiomerically enriched (S)-ethyl 3-hydroxy 4,4,4-trifluorobutanoate using whole cells of Candida parapsilosis ATCC 7330

This work represents facile, simple and relatively 'green' methods to produce optically active fluorine containing β-hydroxy ester which is an important chiral synthon. Following are the important features of the work which exemplifies its significance.