Decarboxylation of fluorosulfones for the preparation fluoroalkylidene precursors

The synthesis of fluorosulfones by alkylation of fluoroacetate derivatives is reported. Their decarboxylation reaction under Krapcho conditions is a convenient process to prepare fluorosulfones as reagents for fluoroalkene synthesis.

Krapcho decarboxylation of benzothiazolylsulfones opens up an improved route for the synthesis of fluorosulfones as Julia–Kocienski reagents.Figure optionsDownload as PowerPoint slideHighlights
► Alkylation of heterocyclic fluorosulfones.
► Decarboxylation of fluoroester.
► Synthesis of fluorosulfones.