Synthesis of 1-aryl-4-tosyl-5-(trifluoromethyl)-1H-imidazoles

• Synthesis of new series of 9 trifluoromethyl-containing imidazoles.
• This method has the ability to tolerate a wide variety of substitutions.
• Compounds were characterized adequately by various spectral data and CHN analysis.
• Newly synthesized compounds exhibited potential biological activity.

A new synthetic protocol for the synthesis of 1,4,5-trisubstituted imidazoles containing trifluoromethyl group has been developed using van Leusen reaction, which incorporates two-component condensation reaction trifluoroacetimidoyl chlorides with tosylmethylisocyanide. This protocol provides a novel and improved method for obtaining trifluoromethyl containing 1,4,5-trisubstituted imidazoles in good yields.

Figure optionsDownload as PowerPoint slide