کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1314147 | 975947 | 2011 | 4 صفحه PDF | دانلود رایگان |
Tetraethyl fluoromethylenebisphosphonate in the presence of cesium carbonate in DMF undergoes efficient 1,4-addition to Michael acceptors having terminal double bond such as α,β-unsaturated ketones, esters, sulfones, sulfoxides, and phosphonates to yield the corresponding adducts (α-alkyl-α-fluoromethylenebisphosphonates) in good to excellent yields.
Tetraethyl fluoromethylenebisphosphonate in the presence of cesium carbonate in DMF undergoes efficient 1,4-addition to Michael acceptors having terminal double bond such as α,β-unsaturated ketones, esters, sulfones, sulfoxides, and phosphonates to yield the corresponding adducts (α-alkyl-α-fluoromethylenebisphosphonates) in good to excellent yields.Figure optionsDownload as PowerPoint slideHighlights
► 1,4-Addition of tetraethyl fluoromethylenebisphosphonate to alfa,beta-unsaturated compounds.
► Michael acceptors having terminal double bond provide alfa-alkyl-alfa-fluoromethylenebisphosphonates in good yields.
► Michael acceptor having terminal triple bond give a mixture of E and Z adduct in moderate yield.
► Beta-substituted Michael acceptors are unreactive.
Journal: Journal of Fluorine Chemistry - Volume 132, Issue 5, May 2011, Pages 363–366