کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1314148 | 975947 | 2011 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: A facile tandem reaction to access β-hydroxy-α,α-difluoroketone derivatives catalyzed by titanocene dichloride/magnesium A facile tandem reaction to access β-hydroxy-α,α-difluoroketone derivatives catalyzed by titanocene dichloride/magnesium](/preview/png/1314148.png)
Tandem reactions of Barbier-type allylation, Brook rearrangement and fluoride-promoted aldol reaction were developed, which afforded a facile, “one-pot” process to β-hydroxy-α,α-difluoroketone derivatives with good to excellent yields.
Tandem reactions of Barbier-type allylation, Brook rearrangement and fluoride-promoted aldol reaction were developed, which afforded a facile, “one-pot” process to β-hydroxy-α,α-difluoroketone derivatives with good to excellent yields.Figure optionsDownload as PowerPoint slideHighlights
► Applied the Cp2TiCl2/M (M = Mg or Zn) system to allylation of trifluoroacylsilanes for the first time.
► Developed a tandem reaction of barbier-type allylation, brook rearrangement and mukaiyama-aldol addition.
► The tandem reactions didn’t go smooth without TBAT.
Journal: Journal of Fluorine Chemistry - Volume 132, Issue 5, May 2011, Pages 367–372