HBF4·OEt2: An efficient fluorinated acid catalyst for the one-pot synthesis of secondary and tertiary N-homoallylic carbamates

• HBF4·OEt2 is used as a catalyst for the first time in this reaction.
• HBF4·OEt2 is used as superior alternative to metal triflates and other catalysts.
• The broad substrates compatibility of HBF4·OEt2 makes this method more useful.
• This method is operationally simple and easily scalable.
• A mechanism is also proposed by showing the catalytic involvement of HBF4·OEt2.

An efficient method for the one-pot synthesis of secondary and tertiary N-homoallylic carbamates using catalytic amount of HBF4·OEt2 is described. The reaction proceeded smoothly to afford the corresponding N-homoallylic carbamates in good to high yields. Operationally simple and easily scalable features make this method more practical over existing methods. Use of HBF4·OEt2 as an acid catalyst also proves the catalytic activity of fluorinated acid catalyst in this important organic transformation.

Figure optionsDownload as PowerPoint slide