کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1314244 | 1499334 | 2014 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Fast and efficient microscale radiosynthesis of 3′-deoxy-3′-[18F]fluorothymidine Fast and efficient microscale radiosynthesis of 3′-deoxy-3′-[18F]fluorothymidine](/preview/png/1314244.png)
• [18F]FLT was synthesized on a micro-scale level.
• Several factors on [18F]fluorination efficiency were examined.
• [18F]FLT was prepared with higher radiochemical yield.
• [18F]Fluorination efficiency can be changed by bulky alcohols.
Microscale radiosynthesis on a miniaturized device has been reported as a promising tool for positron emission tomography. Here, we studied miscroscale-level radiosynthetic conditions by examining several microscale reactions that affect the radiochemical yield of 3′-deoxy-3′-[18F]fluorothymidine ([18F]FLT). [18F]FLT was prepared with 3-N-Boc-5′-O-dimethoxytrityl-3′-O-nosyl-thymidine using the cartridge purification method. [18F]FLT was prepared with a yield of 71%, and the product's purity was greater than 99%. Our results provide a new guideline for microscale [18F]FLT radiosynthesis.
Novel microscale radiochemical synthesis of [18F]-3′-deoxy-3′-fluorothymidine ([18F]FLT) with an enhanced yield is described.Figure optionsDownload as PowerPoint slide
Journal: Journal of Fluorine Chemistry - Volume 166, October 2014, Pages 104–109