Polyfluoroalkylation of 2-aminothiazoles

An efficient, highly selective method for polyfluoroalkylation of 2-aminothiazole derivatives was described. Interestingly, a defluorinated reductive 2-aminothiazole derivative was obtained in moderate yields when 2-aminothiazole was reacted with (CF3)2CFI.

An efficient, highly selective method for polyfluoroalkylation of 2-aminothiazole derivatives was described. Interestingly, a defluorinated reductive 2-aminothiazole derivative was obtained in moderate yields when 2-aminothiazole was reacted with (CF3)2CFI.Figure optionsDownload as PowerPoint slideHighlights
► Highly selective polyfluoroalkylation of 2-aminothiazole.
► Transition-metal free efficient trifluoromethylation of heterocycles.
► Defluorinated reductive hexafluoro-isopropylation of 2-aminothiazole with (CF3)2CFI.