Transition metal-catalyzed cyclopropanation of alkenes in fluorinated alcohols

The system hexafluoroisopropanol/ethyl diazoacetate/Cu(OTf)2 is efficient for the cyclopropanation reaction. The process is experimentally simple, and efficient with various olefins in particular terminal, disubstituted double bonds.

The system hexafluoroisopropanol/ethyl diazoacetate/Cu(OTf)2 is efficient for the cyclopropanation reaction. The process is very easy to realize, and efficient with various olefins in particular terminal, disubstituted double bonds.Figure optionsDownload as PowerPoint slideHighlights
► The system hexafluoroisopropanol/ethyl diazoacetate/Cu(OTf)2 is efficient for the cyclopropanation reaction.
► The advantages of these new solvent conditions is the lack of specific experimental requirements.
► The process is compatible with various olefins in particular terminal, disubstituted, double bonds.