Convenient synthesis of fluoroalkyl α- and β-aminophosphonates

Addition of both alkyl phosphites and phosphonate α-carbanions to N-substituted aldimines derived from fluoroalkyl aldehydes presents a convenient method for synthesis of fluoroalkyl α- and β-aminophosphonates in good yield (55–86%) under mild conditions.

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► Procedure for the preparation of fluoroalkyl α- and β-aminophosphonic acid derivatives.
► Addition of alkylphosphites and phosphonate α-carbanions to N-substituted fluoroalkyl aldimines under mild conditions.
► Substituents on the nitrogen can be removed using standard methods.