The synthesis of 1,5-benzodiazepines in a fluorous aqueous emulsion

The synthesis of 1,5-benzodiazepine derivatives was smoothly carried out in a fluorous aqueous system composed of perfluorooctane (C8F18) and potassium perfluorooctanesulfonate (C8F17SO3K, KFOS) at room temperature. The aqueous perfluorinated emulsion can be recovered by simple extraction and used again without a significant loss of efficiency.