Titanium tetrafluoride: An efficient Lewis acid and fluorinating agent for stereoselective synthesis of 4-fluorotetrahydropyran

Titanium tetrafluoride can efficiently be used for strereoselective synthesis of 4-fluorotetrahydropyrans via Prins cyclization in good yields. The method is general and can be used for aldehydes as well as ketones.

Titanium tetrafluoride can efficiently be used for strereoselective synthesis of 4-fluorotetrahydropyran via Prins cyclization in good yield. The method is general and can be used for aldehydes as well as ketones.Figure optionsDownload as PowerPoint slide