Synthesis of functionalized α-CF3-α-aminophosphonates via Cu(I)-catalyzed 1,3-dipolar cycloaddition

A convenient method for the preparation of α-CF3-α-aminophosphonates bearing alkynyl group at the α-carbon atom has been described. New alkynylphosphonates have been further utilized in the synthesis of functionalized triazole-containing α-CF3-α-aminophosphonates via copper-catalyzed (3+2)-cycloaddition to different organic azides.

An efficient method for the synthesis of triazole-containing α-CF3-α-aminophosphonates has been developed via Cu(I)-catalyzed (3+2)-cycloaddition of the corresponding alkynes to different organic azides.Figure optionsDownload as PowerPoint slide