کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1314581 | 1499349 | 2013 | 6 صفحه PDF | دانلود رایگان |
• An easy metal-free access to 2-perfluoroalkylated benzoxazolines and benzothiazolines.
• The reaction was easily achieved under mild conditions in high yields and purity.
• Study on the scope and regiochemistry of the reaction.
• The protocol uses readily available methyl 2-perfluoroalkynoates as fluorine-containing building block.
The synthesis of 2-perfluoroalkylated benzoxazolines and benzothiazolines was easily achieved under mild conditions in high yields and purity. The protocol uses readily available methyl 2-perfluoroalkynoates as fluorine-containing building block, and furnished the expected product in good to excellent yields in MeOH under reflux for 10 h. This novel synthetic protocol is efficient and general. A plausible mechanism for this process is proposed.
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Journal: Journal of Fluorine Chemistry - Volume 151, July 2013, Pages 20–25